I have 2 boxes and 2 remotes.
One remote is the droidbox vip plus.
The older one is the droidbox s77 equivalent which they no longer do.
Both worked out of the box.
I didn't need to touch settings.
I notice in the version of android my box runs (5) under settings there is a "remote and accessories" tab. Remote is set to "off". Whether that makes any difference i can't say.
If your box has the droidbox share server app installed, you could install the droidbox share client app from the google play store on a phone or tablet and see if that allows mouselike control. I have tested this just now and it definitely allows you to drag icons around the screen on a nova wallpaper.